"A three month old infant shows frequently occurring stereotypical, dancing-like movements throughout the body and limbs. A noted absence of them is highly predictive of later emergence of CP," says Sampsa Vanhatalo, professor of clinical neurophysiology, University of Helsinki.
A very early identification and subsequent therapeutic intervention would be highly beneficial for alleviating the neurodevelopmental impact of CP. Currently, a child is diagnosed with CP at much later age, typically between 6 months and 2 years of age. GM analysis holds promise in early detection of CP, however, it needs special expertise that is currently obtained through international teaching courses, which effectively limits the number of doctors or therapists with the relevant skills. In addition, GM analysis in its present form is based on visual assessment, which is always subjective.
"There is an urgent need for objective and automated methods. They would allow employing movement analyses at much wider scale, and make it accessible to basically most, if not all, children in the world," says Vanhatalo.
Researchers at University of Helsinki and University of Pisa set out to explore the possibility that a conventional video recording of an infant lying in bed could be transformed to a quantified analysis of infant movements. They collaborated with people from an AI company based in Tampere, Neuro Event Labs, who were able to create a method for an accurate extraction of children's movements (using a technique known as pose estimation), allowing for the construction of a simplified "stick man" (or skeleton) video.
Next, the researchers gave the the stick figure videos to doctors with GM expertise to see whether diagnostically crucial information was preserved in those videos.
Using the stick figure videos alone, the doctors were able to assign diagnostic groups in 95% of cases, proving that the clinically essential information had been preserved.
Use of stick figure videos also enables world-wide sharing among research communities without privacy concerns. This has been a significant bottleneck in setting up multinational research activities within this domain.
"This will finally enable a genuinely Big Data kind of development for better quantitative movement analyses in infants," Vanhatalo states.
"Since this study, we have collected larger datasets, including 3D video recordings, and we are currently developing an AI-based method for infantile motor maturity assessment. The rationale is straightforward: there is a developmental issue with the child, if the computational assessment of the motor maturity does not match with the child's true age."
In addition to early CP detection, automated movement analyses have many potential applications in the assessment of infant neurological development.
"We could create one kind of functional growth chart," says Vanhatalo.
Movement analyses could also be used in diverse ways to improve therapeutic decisions. Such methods could provide quantitative means to objectively measure efficacy of different therapeutic strategies; one of the global hot topics in restorative medicine.
Automated movement analyses could also allow out-of-hospital screening of children to identify those that need further care, or to provide assurance of normality in cases with concern about child's development.
"Use of machine learning and artificial intelligence allows for the extraction of substantial amounts of clinically useful information from a simple home-grade video recording. The ultimate aim is to find methods that will make it possible to provide high and even quality infant healthcare everywhere in the world," Vanhatalo summarizes.
MEDICA-tradefair.com; Source: University of Helsinki
